TY - JOUR AU - V. Arun Nivasa, R. Senthamaraia, A. M. Ismailb, T Shri Vijaya Kirubhaa, S. Shakila Banuc, PY - 2020/11/02 Y2 - 2024/03/29 TI - IN SILICO APPROACHES ON PHYTOCHEMICAL COMPONENTS OF CITRUS LIMETTA RISSO FOR THEIR SARS-COV-2 INHIBITORY ACTION JF - PalArch's Journal of Archaeology of Egypt / Egyptology JA - J Arch.Egyptol VL - 17 IS - 9 SE - DO - UR - https://www.archives.palarch.nl/index.php/jae/article/view/5097 SP - 5780 - 5790 AB - <p>The Novel Corona virus (Covid-19) belongs to a family of viruses called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is currently challenging the global health. The first case of Covid-19 was reported and confirmed in Wuhan, China on December 31, 2019 and on January 30, 2020, the WHO (World Health Organisation) declared the outbreak as a public health emergency of international concern and on March 12 announced as pandemic due to its wide spread. Various treatment and management have been in progress on wide ranges. Molecular docking is a virtual screening method that cutback the expenses and time duration for identification of pharmacophore from natural products. This <em>in silico</em> study has been deployed to screen the phytochemical components D-limonene, α-pinene, β-pinene, Camphene, present in <em>Citrus limetta</em> Risso (Rutaceae) against the protein target of Corona virus, including SARS CoV-2 main protease, RNA-dependent RNA-polymerase and Spike receptor binding domain with the aid of AutoDock Vina software. The results obtained after docking showed a good binding affinity and implicated that the active phytoconstituents of the selected plant would be a supportive measure for the management of this pandemic disease upon further investigation.</p> ER -