Analysis the Effects of leakage conductance on the Action potential of Excitable cell using GUI

Abstract

The Hodgkin-Huxley (HH) model of a neuron was developed mathematically in 1952 and had its importance in modern neurobiology. Numerous variants of this presented model have already been established. Still, neuroscientists have so far utilized the HH model of the axonal membrane, which works by taking the help of circuit analog. With the involvement of several biological phenomena of the membrane in addition to the conductance, this model can easily reproduce electrophysiological measurements with almost a high degree of accuracy.

The dynamics of the HH model is related to different neurological and pathological diseases such as Parkinson’s, epilepsy, Addison, Alzheimer’s disease, pathological heart rhythms, etc. Dynamics of HH parameters relate to an electrochemical imbalance in the body, which mainly responsible for the generation of an action potential. The action potential is simulated in graphical user interface using MATLAB